New Main Quest: Uncover the secrets of West Virginia by playing through an all-new main quest, starting from the moment you leave Vault 76. Human NPCs: Befriend or betray new neighbors who have come to rebuild, and experience Appalachia through the eyes of its residents. New Creatures and Gear: Take down newly mutated creatures finding their way to the region and earn the highest tier of weapons and armor. Choices and Reputation: Alter the fates of those you meet with dialogue trees. Decisions affect your standing with each faction through an all-new reputation system.